Why choose the treatment with cisplatin for BRCA1 breast cancers patients?
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چکیده
Patients and methods 50 women with breast cancer and a BRCA1 mutation, who presented with stage I to III breast cancer between December 2006 and April 2010 were enrolled and treated with cisplatin 75 mg/m every three weeks for four cycles, followed by mastectomy and conventional chemotherapy. Eight patients had prior chemotherapy for a previous cancer diagnosis. Three patients received prior chemotherapy for their current cancer diagnosis but received protocol therapy and thus were followed for toxicity and evaluated for response. Information was collected on clinical stage, grade, hormone receptor status and Her2neu (HER2) status prior to treatment. Pathologic complete response was determined by review of surgical specimens.
منابع مشابه
Cisplatin in breast cancer treatment in BRCA1 carriers
A) Neoadjuvant therapy Eighty women with breast cancer and a BRCA1 mutation with stage I, II, and III breast cancer between December 2006 and February 2012 were entered into this study. Patients were treated with cisplatin 75 mg/m2 intravenously every three weeks for four cycles. After chemotherapy, patients underwent surgery and were assessed for pathologic response in both the breast and axil...
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